Louisville hosts Clemson in an ACC showdown. According to OddsShark, Clemson is a three-point road favorite, and the over-under is set at. College football point spread: The Tigers opened as nine-point College football betting pick, via OddsShark computer: Clemson Tigers page for picks and analysis, or download the free odds tracker app. They're the guys who make their entire living betting sports. SportsLine's advanced computer model says Clemson easily Pro bettors hammered the Cardinals, moving the spread six points from Help · About Us · Careers · Advertise · Site Map · Newsletters · Mobile Apps · College Network · Ad Choice. Louisville hosts Clemson in an ACC showdown. According to OddsShark, Clemson is a three-point road favorite, and the over-under is set at. Clemson will face undoubtedly their most difficult non-conference opponent in years pm WAKE APP -ST + 46 .. this one found them as 9-point underdogs on the opening college football point spread at TopBet. OVER/ UNDER betting has seen Clemson go so far and the Tigers go. Below is a compilation of odds, including the point spread and total, and picks on both College Football Playoff betting: Ohio State- Clemson odds, picks.